Urate Lowering Effects of Milk Explored


Ingestion of dairy products has been associated with a lower risk of gout in observational studies. However, the mechanism underlying this protective effect is unstudied. In addition, the association could be related more to health behaviors associated with milk drinking, such as better general health and less consumption of alcohol and red meat, rather than […]

Are TNF Inhibitors Efficacious for the Treatment of Sciatica?


Inflammatory cytokines are implicated in the painful symptoms of sciatica, a common form of lumbar radiculopathy associated with intense pain and dysfunction. Case reports have suggested that TNF inhibitors may improve pain in individuals with sciatica. However, since sciatica is often self-limited, uncontrolled reports of efficacy may be misleading. Here, Genevay et al (Arthritis Rheum […]

Does Antioxidant Intake Protect Against the Development of Rheumatoid Arthritis or Lupus?


Antioxidants may protect tissues against damage, reduce systemic inflammation, and modulate antigen presentation by inflammatory cells.  However, no large-scale investigation on whether dietary and/or supplement intake of antioxidants is protective against the development of autoimmune rheumatic disease.  Here, Costenbader et al (American Journal of Epidemiology 2010; 172(2): 205) explore antioxidant intake and the risk of […]

Are the Incidence and Prevalence of RA Changing in the United States?


The epidemiology of rheumatoid arthritis (RA) is influenced by a number of factors, including survival, changes in diagnostic tools, and temporal trends in environmental factors that may promote or protect from disease.  Here, Myasoedova et al (Arthritis Rheum 2010; 62(6): 1576) explore the trends in RA incidence and prevalence over 50 years in a population-based […]