Certolizumab pegol (Cimzia®) gained FDA approval in September/October 2013 for two new indications, adults with active psoriatic arthritis (PsA) and adults with active ankylosing spondylitis (AS).
Ankylosing Spondylitis News
TNF-α blockade in patients with ankylosing spondylitis (AS) has been shown to improve clinical symptoms of disease and physical function. However, a benefit in reducing the incidence or severity of […]
Tumor necrosis factor alpha (TNF-a) is a highly inflammatory cytokine with an important role in coordinating the inflammatory response seen in the axial skeleton of patients with ankylosing spondylitis (AS). Two biologic inhibitors of this cytokine, etanercept (Enbrel) and infliximab (Remicade), have been shown to be effective at reducing the subjective symptoms and reducing the systemic inflammatory response in AS in randomized clinical trials.
Infliximab (Remicade®) is now approved in Europe for the treatment of ankylosing spondylitis (AS) patients who have severe axial symptoms, elevated serological markers of inflammatory activity and who have had an inadequate response to conventional therapy.