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Ocrelizumab, a Humanized Anti-CD20 Monoclonal Antibody, Studied for the Treatment of RA
Rheumatoid Arthritis News
FDA Arthritis Advisory Board Recommends the Approval of Tocilizumab (Actemra) for the Treatment of RA
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Immune Tolerance Induced by Chicken Type II Collagen as Treatment for RA
Type II collagen is abundant in the joint and is a major target of immune-mediated damage in RA. As suggested in studies of experimental animals, induction of immune tolerance at the level of the cartilage may be a way of reducing the signs and symptoms of RA and prevent joint destruction. However, whether oral administration of Type II collagen is an efficacious treatment for humans with established active RA has not been established.
Increasing the Dose of Etanercept not Efficacious in Rheumatoid Arthritis
Increasing the dose of infliximab and, in some cases, adalimumab can result in improved efficacy in RA patients with inadequate responses to initial dosing. However, whether increasing the dose of etanercept can also result in clinical improvement has not been studied.
Denosumab suppresses erosions but has no effect on articular signs and symptoms in rheumatoid arthritis
Bone erosions in response to inflammation in RA are driven by osteoclasts which are in turn activated by RANKL (Receptor Activator for Nuclear Factor κ B Ligand) binding to its receptor RANK. Inhibition of RANKL has the potential to retard bone erosions in RA patients, thereby limiting progressive joint damage and destruction.
Golimumab Shows Promise for the Treatment of Rheumatoid Arthritis
Arthritis News : Golimumab Shows Promise for the Treatment of Rheumatoid Arthritis
