…TNF inhibitors (e.g. infliximab and adalimumab) compared with decoy receptor TNF inhibitors (e.g. etanercept), there have been few direct comparisons. Here, Dixon et al (Ann Rheum Dis 2010; 69: 522-528)…
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Treatment of Rheumatoid Arthritis with Anakinra (Kineret®) in combination with Methotrexate
…(Arthritis Rheum 46(3):614-624, 2002) examined the safety and efficacy of anakinra in combination with methotrexate compared to methotrexate alone. Methods: In this study 419 subjects were studied who had moderate-to-severe…
FDA Arthritis Drug Advisory Committee Recommends Approval of Febuxostat for Treatment of Hyperuricemia of Gout
…advisory committee. Febuxostat is similar to the most commonly used urate lowering agent, allopurinol, in that it inhibits xanthine oxidase, an important intermediate in the production of uric acid. However,…
New Onset Psoriasis may be Increased in TNF Inhibitor User
…Rheumatology Biologics Register (BSRBR) Methods Biologic-treated RA patients enrolled in the BSRBR were compared to a comparison cohort of non-biologic treated patients for incident psoriasis. Those identified by their treating…
Does Bone Marrow Edema Predict Progression of Knee Osteoarthritis
…the lateral compartment. In terms of progression of knee OA, of the 39 knees demonstrating progressive joint space narrowing (JSN) of the medial compartment, 27 (69.2%) had medial bone marrow…
Etanercept and Methotrexate Combination Therapy for Rheumatoid Arthritis Treatment
…of disease activity, as compared to 29% of the 30 patients receiving methotrexate plus placebo. By 24 weeks, 39% of the methotrexate plus etanercept met the ACR 50 criteria compared…
