I’ve been treated for pmr/connective tissue disease for 4 years. After being on low dose prednisone for three years, I’ve been off it for one year while taking 20 mg methotrexate/week and 400 mg of plaquinal daily. I tolerated the prednisone fine but my Dr. felt it was worth the effort to get off but I’m ready to start up again because the pain is too much. What about rituxin? If there was a good chance it would help, I’d find a way to pay out of my own pocket. My rheumy feels it might be a few years before data would warrant such a course. Prednisone or rituxin?