…invasive fungal infections, observed occasionally with TNF inhibitors. There were no reports of these types of infections among patients receiving apremilast. Typical infections with apremilast appear to be mild, with…
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Golimumab Shows Promise for the Treatment of Rheumatoid Arthritis
…to 88% of those in the combined golimumab groups. By week 52, 60% of patients in the placebo group remained compared to 79% in the combined golimumab groups (p=0.02). Table….
Synergistic Benefit Combining Inhibitors of Interleukin-1 and Tumor Necrosis Factor in Rheumatoid Arthritis Model
…comparing the benefits of combination therapy with interleukin-1 receptor antagonist (IL-Ra) and PEGylated soluble tumor necrosis factor receptor type I (PEG sTNFRI) in a rat model of rheumatoid arthritis. Rats…
The IL-6 Receptor Antagonist Tocilizumab Shows Promise for the Treatment of RA
…subjects receiving 2 mg/kg monotherapy and 3 in 3 subjects receiving 8 mg/kg combination therapy) and included limb abcess/osteomylelitis, pleural infection, lower respiratory tract infection, infective arthritis, 2 cases of…
The Combination of Leflunomide (Arava) and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis
…was reached. The most common adverse events, mild to moderate in intensity, were diarrhea, upper respiratory infection, nausea, headache, rash dizziness, and alopecia. The frequency of infections was less in…