I have been on Humira for 5 months, & initially had a a great response to the first two injections. Since then it doesn’t seem to have been as effective. As i can’t take Methotrexate i have been increased to weekly Humira injections. I have now had 4 weekly consecutive jabs but still have not felt the same response i first felt with my very first 2 injections. Does this mean it isn’t working for me any more? My last blood test showed a CRP rate of 110, after my first jab it fell to just 23, but has increased steadily since to the current 110 rate. I know it can can take 2-12 weeks to feel full benefit, but as i’d been on 2 weekly jabs for 5 months already, I had hoped for a faster response to weekly jabs? Embrel failed for me & i developed a rection to Remicade & had to be taken off it, so Humira is my last hope as far as Anti TNF is concerned.
Given that you do not have many options left, I would give weekly Humira a 3 month trial before giving up.