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Home / Ask the Expert / Surgery and Methotrexate dosage.

Surgery and Methotrexate dosage.

October 15, 2007 By Arthritis Center

Question

I am having an upper eyelid blepharoplasty and wonder what your recommendations are for how long I should stay off methotrexate before and after the surgery? I take .6 ml of mtx weekly.

Answer

Methotrexate (MTX) does not have to be stopped prior to surgery.  There is very little risk of infection post-surgery with this medication.  We rheumatologists use very small doses of MTX to treat RA.  The oncologists use much larger doses to treat cancer and there is more of an infectious risk in that situation.

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