The FDA approval for both drugs is the same. “Simponi is indicated for the treatment of adult patients with active ankylosing spondylitis””.”” Humira is indicated for reducing signs and symptoms in adult patients with active AS.”” Both medicaations inhibit a cytokine called TNF or tumor necrosis factor. There is no way to predict which will work better or if either will work at all. While TNF inhibitors have helped many people by curbing the progression of AS
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