There have been a variety of skin conditions associated with the TNF inhibitors (Remicade, Humira, Enbrel). They have included eczema, worsening skin psoriasis, pustular psoriasis and allergic reaction. I am not aware of any information about changes from 25 mg twice weekly to 50 mg weekly of Enbrel causing any problems. I am also not aware of HRT changing the course of psoriasis.
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