I have RA and Plaquenil just got added to NSAID, MTX, and Prednisone. I am taking 400mg of Plaquenil, 20mg MTX, and 10mg Prednisone. I have only taken the Plaquenil for four days and every day I have a headache. It is not like a regular headache. It feels like someone has their hands on top of my head and pushing down on my head. Like I have pressure on the top of my head. I nver had this before. Could this be a side effect of the Plaquenil and does it normaly go away after I take it for a while?
That is an unusual side effect for Plaquenil. I would try stopping and restarting it to make sure Plaquenil is at fault.