greetings, im a physician and newly diagnosed spondyloarthropic. ive seen several researchers point toward phopshpocitrate as a potent inhibitor of tgf-beta in murine models of AS (j cliford, h krug). infact, its use appears to inhibit or stop ankylosis altogether. i believe bisphosphonates failed to have a similar effect in mice. despite clinical improvement in humans, i know its unclear what effect bisphosphonates have with regard to ankylosis. my question is: are there plans to test phopshpcitrate, or prehaps closer cousins to it, in humans? enjoy, josh
Great question. I haven’t heard of any trials yet with this but will keep my ears and eyes open.