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Home / Ask the Expert / Minocycline Trials

Minocycline Trials

July 16, 2007 By Arthritis Center

Question

Why do you guys ignore the NIH study that proved in a placebo controlled trial minocycline was far more effective than placebo for RA? There is also a correlation w RA and an animal model with the microbe mycoplasma. Dont patients have a right to know this? On your page the reasearch is funded by drug companies, could that be why?

Answer

This forum has acknowledged on numerous occasions that minocycline has been extensively studied in human RA and has a modest benefit in the clinical trials. However, minocycline is not as effective as the newer biologic agents and is overall disappointing when used in our regular patients. The NIH did a large study in early human RA looking for a microbe that might cause RA using biopsies and cultures and PCR. The study failed to show a link with mycoplama or any other infection. Animal models do not replicate human RA. We also acknowledge that pharmaceutical companies help to fund this site and we work hard to maintain editorial independence. All funds are unrestricted and there is absolutely no input from the companies as to topic or content. We wish that there were other means to support our site so any contributions are welcome.

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