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Home / Ask the Expert / methotrexate toxicity

methotrexate toxicity

April 9, 2007 By Arthritis Center

Question

I take a relatively low dosage of methotrexate once a week. I feel weak, tired and slightly sick for a day and a half after each dose. I also take hydroxychoroquine. I stopped the methotrexate for a couple of weeks and felt great but towards the end of the two weeks my RA symptoms returned. My blood work is normal. I don’t want to get 5 days of relief for two days of feeling sick every week. Are there other DMARDS that I should try?

Answer

Talk to your rheumatologist and look at our RA treatment section on this website. Arava (leflunomide) or one of the TNF inhibitors (Humira, Enbrel, Remicade) might be appropriate.

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