This depends on how well you tolerate prednisone and if you have other conditions (diabetes, high blood pressure, osteoporosis, herat disease, obesity) that might be worsened with prednisone. In general, if you are at 5 mg or less of prednsione, it is not worth the risk and hassle of adding methotrexate.
About Alan Matsumoto, M.D.
Part-time Faculty, Division of Rheumatology
Johns Hopkins University