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Home / Ask the Expert / is it possible to gain weight on methotrexate??

is it possible to gain weight on methotrexate??

April 5, 2007 By Arthritis Center

Question

I am being treated for systemic Lupus–I have been taking Methotrexate 2.5mg (10 pills 1x a week) for the past 7 months–my weight has some how crept up at least 5-10 lbs–could this contribute to my weight increase?? im a bit frustrated, so im trying to figure this out.

Answer

I do not think that MTX itself is causing weight gain.

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