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Home / Ask the Expert / Can Methotreate cause nerve pain/neuropathy?

Can Methotreate cause nerve pain/neuropathy?

April 5, 2007 By Arthritis Center

Question

I have been taking methotreate (10 mg a week) for 13 years for psoriatic arthritis. I have developed very servere nerve pain in my feet and ankles. The EMG and nerve conduction studies were negative. A pain specialist mentioned that it was possibly a result of the methotreate. I have not heard that this could be a side effect. Do you have any information on this?

Answer

I am not aware of methotrexate causing a peripheral neuropathy.

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