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Home / Ask the Expert / Can Methorexate cause gastritis or aggravate it?

Can Methorexate cause gastritis or aggravate it?

April 3, 2007 By Arthritis Center

Question

I have been on methorexate for about 2 yrs. for Takayasus.Was having stomach problems and was switched to injections (15mg). Have been off 2 mos. of steroids and just on MTX injection once a week. Have been diagnosed with gastritis and am wondering if I should be taken off Methotrexate completely, since the Prevacid that I am taking twice a day is not helping, or try another stomach medicine, or could this be prendisone withdrawal.

Answer

Although methotrexate can cause stomach upset both with the oral tablets and injections, it does not specifically cause gastritis. In my experience, the stomach problems with methotrexate tend to occur when the drug is first started.

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