zero negative rheumatoid arthritis


what is this compared to positive rehumatoid arthritis and can the above mentioned turn into positive arthritis. what is my future prognosis. I am a soon to be 47 yr old female.


Rheumatoid factor is a commonly ordered blood test to help diagnose rheumatoid arthritis. About 70-90% of people with adult rheumatoid arthritis are positive for rheumatoid factor and about 20% of people remain negative for rheumatoid factor even though they have been diagnosed with rheumatoid arthritis. Therefore, a positive test for rheumatoid factor is by no means necessary to indicate disease.

The result does not correlate with the activity of disease, but patients with a high amount rheumatoid factor are more likely to have erosive joint disease, extra-articular manifestations, and greater functional disability. In contrast, generally, rheumatoid factor negative patients exhibit a milder disease course.

Alan Matsumoto, M.D.

About Alan Matsumoto, M.D.

Part-time Faculty, Division of Rheumatology
Johns Hopkins University