Seropositive simply means that your rheumatoid factor blood test is positive. Some also count the anti-CCP positive test as seropositive. In general, patients develop positive rheumatoid factor within one year of developing symptoms. Overall, patients who are seropositive have a more severe disease course with more joint deformities, x-ray damage, disability and inflammation outside of the joints. However, there are many exceptions to these rules.
About Alan Matsumoto, M.D.
Part-time Faculty, Division of Rheumatology
Johns Hopkins University