I am not aware of any studies, but make sure the injections are going into the subcutaneous tissue (see our website section on injection technique).
Proper subcutaneous injection technique
October 29, 2007 By
Question
I did an experiment, I am on enbrel for 3 months now and was getting a reaction at the site each time, so for 4 injections I pressed the auto injector down into my thigh a bit harder and notiiced no reaction at the site, it bled a little but that was all. So this past week I let up and did it with a lighter pressure and low and behold got a reaction. My question is do you think when it goes in a bit deeper it keeps it from pooling in the upper dermis and irratating the surrounding tissue? Has anyone looked into this?
Answer
About Alan Matsumoto, M.D.
Part-time Faculty, Division of Rheumatology
Johns Hopkins University
