Pregnancy and Methotrexate


I was taking methotrexate 8 pills 1 x a week at 2.5 mg.  I began last August and stopped this past March.  I want to get pregnant but I have some concerns.  I have been reading on the internet that there have been reported cases of birth defects such as spina bifida in women who took methotrexate prior to conception. Is waiting 6 months prior to conception long enough to get the drug out of my system?


Current recommendations is to stop methotrexate for 2 menstral cycles before attempting pregnancy.  Men taking methotrexate should stop for 90 days prior to atempting pregnancy.

Alan Matsumoto, M.D.

About Alan Matsumoto, M.D.

Part-time Faculty, Division of Rheumatology
Johns Hopkins University