Current recommendations is to stop methotrexate for 2 menstral cycles before attempting pregnancy. Men taking methotrexate should stop for 90 days prior to atempting pregnancy.
Pregnancy and Methotrexate
I was taking methotrexate 8 pills 1 x a week at 2.5 mg. I began last August and stopped this past March. I want to get pregnant but I have some concerns. I have been reading on the internet that there have been reported cases of birth defects such as spina bifida in women who took methotrexate prior to conception. Is waiting 6 months prior to conception long enough to get the drug out of my system?