Methotrexate and getting pregnant

Question

My husband takes methotrexate for dermatomyositis. We have 1 child we conceived befoer he got sick. He has been on methotrexate for 2 years. How long does he have to stop before we can try to conceive? Will this affect his fertility?

Answer

Methotrexate should not affect his fertility. In men, methotrexate needs to be stopped 90 days prior to attempting pregnancy. Women need to be off 2 ovulatory cycles (2 menstral periods). Thus is due to the small possibility of birth defects associated with methotrexate use during conception and pregnancy.

Alan Matsumoto, M.D.

About Alan Matsumoto, M.D.

Part-time Faculty, Division of Rheumatology
Johns Hopkins University