Methotrexate should not affect his fertility. In men, methotrexate needs to be stopped 90 days prior to attempting pregnancy. Women need to be off 2 ovulatory cycles (2 menstral periods). Thus is due to the small possibility of birth defects associated with methotrexate use during conception and pregnancy.
About Alan Matsumoto, M.D.
Part-time Faculty, Division of Rheumatology
Johns Hopkins University