Lupus and ANA test

Question

What blood work should be done after a posative ANA test to confirm diagnois of Lupus?

Answer

Hi Brandi,

The diagnosis of lupus is usually made by clinical history and physical examination and some routine blood tests like blood counts, chemistries and urinalysis.  The ANA test is used to confirm the diagnosis.  Nearly always, it is positive in lupus (that means a level greater than 1:320).  IF that is positive, the rheumatologist will often get additional tests like anti-Smith, anti-DNA, complements, etc. because these will mark a patient who is more likely to get kidney involvement and have a bit more severe disease.

Joan Bathon, M.D.

About Joan Bathon, M.D.

Dr. Bathon was a Co-Deputy Director of the Division of Rheumatology at Hopkins Bayview. She was also the founder and director of the Hopkins Arthritis Center.