Long term prednisone vs methotrexate for GCA


Have any clinical trials been done done for GCA using low dose Prednisone alone without Methotrexate? I do not want the side effects of Methotrexate and am able to do fine on low doe Prednisone.


There have been trials with mixed results. If your prednisone can be tapered below 10 mg daily and if you are tolerating it without side effects, then I agree that there is likely no need to look for another drug. Discuss with your doctor.

Alan Matsumoto, M.D.

About Alan Matsumoto, M.D.

Part-time Faculty, Division of Rheumatology
Johns Hopkins University