A link between inflammatory arthritis and periodontal disease has been proposed. In fact, before the days of pharmacotherapy for rheumatoid arthritis, a method of treatment was to pull out the teeth. Still, it remains unclear how the two conditions are related. It is unlikely, however, that the answer is as simple as a persistent infection. Likely periodontal inflammation serves as a trigger for joint inflammation, that may persist even when any potential infectious agent has been removed.