Autologous cartilage replacements have met with limited success, as they tend to not be as durable as native cartilage. In addition, they are only appropriate for people with very small areas of worn cartilage. Knee replacement remains the most effective treatment for advanced symptomatic knee osteoarthritis. In general, the surgery is well tolerated with a low rate of complications and excellent outcomes in the majority of patients. In addition, the devices tend to be very durable, with many prostheses in full operation well past 15 to 20 years.