antibiotics and methatrexate

Question

I have been on methatrexate for 5 weeks. I have LLL pneumonia and am taking leavaquin po daily. Is there a contraindication/ Does the methatrexate inhibit the antibiotic or vice-versa?

Answer

There should not be an issue with Levaquin. Bactrim, (trimethoprim Sulfa) should be used cautiously with methotrerxate because it can increase the toxicity of methotrexate.

Alan Matsumoto, M.D.

About Alan Matsumoto, M.D.

Part-time Faculty, Division of Rheumatology
Johns Hopkins University