There should not be an issue with Levaquin. Bactrim, (trimethoprim Sulfa) should be used cautiously with methotrerxate because it can increase the toxicity of methotrexate.
antibiotics and methatrexate
I have been on methatrexate for 5 weeks. I have LLL pneumonia and am taking leavaquin po daily. Is there a contraindication/ Does the methatrexate inhibit the antibiotic or vice-versa?