What is Lesinurad/Allopurinol (Duzallo®)?
Some people with gout may still have a high uric acid level even though they are on a xanthine oxidase inhibitor such as allopurinol. Lesinurad may be prescribed to help lower your uric acid levels. There is also a single pill that is a combination of Lesinurad and allopurinol known as Duzallo®
How do I take it?
Take one Duzallo pill each morning with food and water. Drink 2 liters of fluid (about 68 ounces) throughout the day while taking Duzallo.
What about side effects?
Before beginning Duzallo treatment, make sure you’ve told your healthcare professional about any medical problems you have. This is especially important if:
- You have liver or kidney problems
- You have a history of heart disease or stroke
- You’re pregnant or planning to become pregnant
- You’re breast-feeding or planning to breast-feed
Your healthcare professional will do blood tests to check your kidney function while you are taking Duzallo. Acute renal failure (kidney failure) has happened with lesinurad (one of the ingredients in Duzallo. This was more likely in people who took lesinurad without taking allopurinol or febuxostat with it.
The most common side effects of Duzallo are headache, flu, higher levels of blood creatinine (a measure of kidney function), and heartburn. Duzallo may cause drowsiness. Use caution driving or operating machinery until you know how Duzallo will affect you.
What about other medications?
When you are taking Duzallo, it is very important that your doctors know if you are taking any other medicine. This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements. You must take lesinurad with your allopurinol or febuxostat.
What else should I know?
Gout may flare up when you start taking any medicine to lower your uric acid. This is caused when crystals begin to dissolve in your joints as your uric acid level goes down. Your healthcare professional may tell you to take other medicines to help prevent or manage flares during initial treatment. If your healthcare professional gives you medicine to lower your uric acid, you should keep taking it, even between attacks.
More information on Duzallo®.