What is Lesinurad (Zurampic®)?
Some people with gout may still have a high uric acid level even though they are on a xanthine oxidase inhibitor such as allopurinol or febuxostat. Lesinurad may be prescribed to help lower your uric acid levels. Lesinurad is commonly known as Zurampic®
How do I take it?
Take one lesinurad pill each morning at the same time as your allopurinol or febuxostat. Remember, you need to take both so they can work together to lower high uric acid.. Do not take more than one lesinurad pill per day
Take lesinurad with food and water. Drink 2 liters of fluid (about 68 ounces) throughout the day while taking lesinurad.
What about side effects?
Before beginning Lesinurad treatment, make sure you’ve told your healthcare professional about any medical problems you have. This is especially important if:
- You have liver or kidney problems
- You have a history of heart disease or stroke
- You’re pregnant or planning to become pregnant
- You’re breast-feeding or planning to breast-feed
Your healthcare professional will do blood tests to check your kidney function while you are taking Lesinurad. Acute renal failure (kidney failure) has happened with lesinurad. This was more likely in people who took lesinurad without taking allopurinol or febuxostat with it.
The most common side effects of lesinurad are headache, flu, higher levels of blood creatinine (a measure of kidney function), and heartburn.
What about other medications?
When you are taking Lesinurad, it is very important that your doctors know if you are taking any other medicine. This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements. You must take lesinurad with your allopurinol or febuxostat.
What else should I know?
Gout may flare up when you start taking any medicine to lower your uric acid. This is caused when crystals begin to dissolve in your joints as your uric acid level goes down. Your healthcare professional may tell you to take other medicines to help prevent or manage flares during initial treatment. If your healthcare professional gives you medicine to lower your uric acid, you should keep taking it, even between attacks.
More information on Zurampic®
Receive the Latest News from Johns Hopkins Rheumatology
Join our mailing list to receive the latest news and updates from Johns Hopkins Rheumatology.