A single nucleotide polymorphism (SNP) in the PTPN22 gene has recently been shown to associate with rheumatoid arthritis (RA) with a strength of association second only to that of the HLA region encoding the MHC class II shared epitope (SE). To date, the mechanism by which the altered PTPN22 gene contributes to the pathogenesis of RA has largely been unstudied.
Arthritis News
Efficacy of Adalimumab in Patients with Active Psoriatic Arthritis
Both etanercept (Enbrel) and infliximab (Remicade) have been shown to be effective in the treatment of psoriasis and psoriatic arthritis in randomized, double-blind, placebo-controlled trials.
Abatacept Receives FDA Approval for Treatment of RA
The Food and Drug Administration (FDA) has now approved abatacept (Orencia®) for the treatment of rheumatoid arthritis (RA). It is the first approved agent to demonstrate efficacy and safety in patients with an inadequate response to TNF antagonists, as well as those with an inadequate response to MTX.
Improved Cardio-Respiratory Fitness with Prescribed Exercise
Regular physical activity improves general health but the frequency and intensity of physical activity required to produce benefits is not clear. To address this issue, Duncan and associates (Archives of Internal Medicine, 2005; 165: 2362-2369) conducted a randomized controlled clinical trial to evaluate the effects of different prescriptions of exercise intensity and frequency on cardiovascular disease risk factors.
Consequences of Physical Activity on Life Expectancy
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Medicare Part D – Medicare’s New Prescription Drug Program
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