High rates of continuation for RA patients switched to second TNF inhibitor

A strong association between chondrocalcinosis, resulting from calcium pyrophosphate dihydrate (CPPD) deposition, and knee osteoarthritis (OA) is firmly established. However, despite the association, a causative pathogenic role for CPPD crystals on the progression of articular degeneration in the knee has not been definitively demonstrated.

Ratio of serum Osteoprotegerin and RANKL predicts radiographic progression in RA

The molecular mechanisms leading to erosive joint damage in some, but not all, patients with rheumatoid arthritis (RA) are incompletely understood. Downstream effects of inflammatory cytokines produced by rheumatoid synovium include the induction of RANKL, a powerful osteoclast activator, the action of which is physiologically opposed by its naturally occurring antagonist osteoprotegerin (OPG).

Pregnancy Outcomes in Patients with Rheumatoid Arthritis and Lupus

Changes in disease activity during pregnancy and the peri-partum period have long been recognized features of systemic autoimmune disease. Moreover, as certain autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), frequently affect women of childbearing age, there is the potential for the disease to affect pregnancy outcomes. However, despite the frequency […]