Despite its prevalence, no effective pharmacotherapies have been definitively proven to modify the course of radiographic knee osteoarthritis (OA). Risedronate, a bisphosphonate that reduces bone turnover, has been shown in animal models to inhibit cartilage degradation and progression of disease.
Mechanical forces exerted on the knee contribute to the development of knee osteoarthritis (OA). Among these, the additional torque about the knee associated with increasing leg length may predispose people of taller stature to knee OA. However, this association has received little prior investigation. In contrast to body height, which may decrease with age, knee height is relatively constant, making knee height a more appropriate surrogate for stature in the elderly.
Total knee replacement (TKR) is an effective, yet underutilized, treatment for severe knee osteoarthritis (OA). In particular, eligible minority patients tend to undergo TKR less often than white patients. The origins of these racial/ethnic disparities are incompletely understood, but may include both care-based (e.g. physician bias for recommending TKR) and patient-based (e.g. decisions not to undergo TKR if recommended) factors.
Preliminary evidence from experimental animal models has suggested that doxycycline may be effective in preventing or slowing the progression of osteoarthritis (OA), perhaps through its ability to modulate the activity of cartilage-degrading matrix metalloproteases (MMPs). Despite this encouraging animal evidence, no studies have investigated doxycycline in humans with, or at risk for, OA. Here, Brandt [...]
Injuries to the internal supporting structures of the knee (i.e., ligaments and menisci) have been shown increase the risk of knee OA, particularly in athletes with knee injuries early in life. Unrecognized degenerative damage to these structures may also predispose to an increased risk of knee OA. Here, Hill et al (Arthritis Rheum 52(3):794, 2005) [...]