Comparison of Febuxostat and Allopurinol on Serum Urate Levels

Study results by Moreland, et al comparing febuxostat with allopurinol in Patients with hyperuricemia and gout are now published (N Engl J Med 353: 2505-2507). In this multicenter study, 760 patients received either febuxostat (80mg or 120mg) or allopurinol (300mg). 53% and 62% of patients receiving 80mg and 120mg, respectively, achieved serum urate concentration levels of less than 360 mmol perliter compared to 21% of patients receiving allopurinol. These data were previously reported at the 2004 American Rheumatology meeting.

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