Are Bisphosphonates Effective in Treating Ankylosing Spondylitis?

Nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy have been the standard of treatment for ankylosing spondylitis (AS) for several decades but neither stops or slows the progression of disease. Pamidronate, a bisphosphonate, has been shown to be effective in animal models of established arthritis. Moreover, pamidronate has appeared to be beneficial in patients with NSAID-refractory […]