…partially due to difficulties in tracking and quantifying specific exposures within complex frameworks, particularly when exposure likely precedes onset of disease by years or even decades. Here, Gold et al…
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RA Pathophysiology
…release of prostaglandins from synovial fibroblasts, and are also potent algesic (pain-producing) agents. Complement may be available for interaction with immune complexes to generate additional chemotactic stimuli. The neuropeptide substance…