Enrolling
CORRONA Data Collection Program
Updated 8/23/2012
Purpose of Study: This research is being done to gather information about patients with certain rheumatic diseases. The CORRONA Organization is building a comprehensive database of information concerning rheumatology patients as part of its mission to facilitate research.esearch is being done to gather information about patients with certain rheumatic diseases. The CORRONA Organization is building a comprehensive database of information concerning rheumatology patients as part of its mission to facilitate research.
Recruiting Patients:
- Diagnosed with Rheumatoid Arthritis or Psoriatic Arthritis
- Patients of the Johns Hopkins Arthritis Center
| Coordinator/Contact: | Michelle Jones 410-5509674 Email: mrkjones@jhmi.edu |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00027956 |
Pilot Study of Implementing the Patient Report Outcomes Measurement Information System (PROMIS) into Clinical Care in Rheumatic Diseases
Updated 8/23/2012
Purpose of Study: This research is being done to test a new questionnaire administered on iPad tablet device. It is designed to facilitate a more focused physician-patient interaction to provide an accurate assessment of your overall health, ability to function and take part in life activities, and other aspects of living with arthritis (such as sleep, fatigue, emotions, etc.).
Recruiting Patients:
- Patients Diagnosed with Rheumatoid arthritis and Psoriatic arthritis
- Established patients at the Johns Hopkins Arthritis Center
| Coordinator/Contact: | Trisha Duncan 410-550-3609 Email: tduncan4@jhmi.edu |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00071923 |
Research Database for Spondyloarthritis Patients
Updated 8/22/2012
Purpose of Study: This research is being done to better understand several important features of “spondyloarthritis”. Our goal is to develop a database with clinical information, blood samples and joint fluid from people with spondyloarthritis to help better understand the condition.
Recruiting Patients:
- Diagnosed with ankylosing spondylitis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease-associated arthritis and undifferentiated arthritis.
- Patients of the Johns Hopkins Arthritis Center.
| Coordinator/Contact: | Michelle Jones Phone: 410-550-9674 Email: mrkjones@jhmi.edu |
| Principal Investigator: | Grant H. Louie, MD, MHS |
| IRB#: | NA_00066578 |
The CORRONA Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions (CORRONA CERTAIN) Sub-study
Updated 8/23/2012
Purpose of Study: This research is being done to find the effectiveness and safety of certain biologic medications used in the management of rheumatoid arthritis (RA). Biologic therapies (including medications like Enbrel, Humira, Remicade, Cimzia, Simponi, Actemra, Rituxan and Orencia) have changed the treatment of RA. The differences in safety and/or effectiveness of each biologic medication are not all known. We are doing this study in order to try to see if one or more of these treatments are better than the others.
Recruiting Patients:
- Diagnosed with Rheumatoid Arthritis
- Patients of the Johns Hopkins Arthritis Center
| Coordinator/Contact: | Michelle Jones Phone: 410-550-9674 Email: mrkjones@jhmi.edu |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00027956 |
A Multi-Center, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination with Methotrexate for Inducing and Sustaining Clinical Response in the Treatment of DMARD-Naïve Adults with Early Active Rheumatoid Arthritis (RA).
Updated 8/23/2012
Purpose of Study: This study is being done to understand if the combination of Certolizumab pegol and methotrexate (MTX) as compared to MTX alone can induce disease remission in patients with early rheumatoid arthritis.
Recruiting Patients:
- Diagnosed with rheumatoid arthritis less than 1year ago
- No history of taking any disease modifying anti-rheumatic drug (DMARD)
- Men and women age 18 and over
| Coordinator/Contact: | Marilyn C. Towns 410-550-0579 Email: mctowns@jhmi.edu |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00070948 |
Ongoing Research
Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis (RA BIODAM)
Updated 7/13/2012
Purpose of Study: The purpose of this research study is to measure how active a patient’s rheumatoid arthritis (RA) is, how to predict what medications will work best, and to predict which patients will develop joint damage over time by identifying biomarkers in the blood and urine.
| Coordinator/Contact: | Marilyn C. Towns |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00041600 |
A Phase I/II Open-label Study to Evaluate The Safety and Efficacy of Abatacept in Subjects With Chronic Urticaria Who Have Had an Inadequate Response to Anti-histamine Therapy. The Abatacept Urticaria Study (TAHOE)
Updated 7/13/2012
Purpose of Study: The purpose of this research study is to determine if abatacept (Orencia ®) is safe and effective in treating people with chronic urticaria (persistent hives).
| Coordinator/Contact: | Marilyn C. Towns |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00017916 |
A Phase 3b, Randomized, Active Controlled Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination with Methotrexate in Inducing Clinical Remission Compared to Methotrexate Monotherapy in Adults with Very Early Rheumatoid Arthritis (RA).
Updated 7/13/2012
Purpose of Study: The purpose of this research study is to understand if the combination of subcutaneous (SC) abatacept and methotrexate (MTX) or abatacept SC alone as compared to MTX alone can induce disease remission in patients with very early rheumatoid arthritis.
| Coordinator/Contact: | Marilyn C. Towns |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00043742 |
Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository (TETRAD)
Updated 7/13/2012
Purpose of Study: The purpose of this research study is to form a large, national database of patients with rheumatoid arthritis (RA) to identify genetic and other factors that contribute to RA. It will also look at responses to various treatments.
| Coordinator/Contact: | Marilyn C. Towns |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00034921 |
An open label study of the efficacy and safety of re-treatments with rituximab (MabThera®/Rituxan®) in patients with active rheumatoid arthritis who have had an inadequate response to anti‑TNFa therapies
Updated 7/24/2012
Purpose of Study: The purpose of this research study is to determine whether additional treatments or an initial treatment with rituximab when given together with methotrexate and intravenous corticosteroids will reduce the symptoms of rheumatoid arthritis and continue to do so safely upon future re‑treatments with rituximab.
| Coordinator/Contact: | Marilyn C. Towns |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| WIRB® I RB#: | 20031958 |
Comprehensive Oral Health Assessment in Patients with Arthritis and Autoimmune Inflammatory Diseases
Updated 7/13/2012
Purpose of Study: The purpose of this research study is to determine whether Periodontal Disease (Gum Disease) is more common or severe in patients with Rheumatoid Arthritis and other Auto immune conditions.
