Johns Hopkins Arthritis Center
Limited data have suggested that the selective-serotonin reuptake inhibitors (SSRIs) may have anti-inflammatory properties in addition to their antidepressant effects. Here, Sacre et al (Arthritis Rheum 2010; 62(43): 683) explore the mechanisms of two SSRIs (fluoxetine and citalopram) in models of experimental arthritis. Methods Inflammation was induced in the paws of male DBA/1 mice by [...]
Despite systemic administered therapies, some patients with inflammatory arthritis continue to have chronic or recurrent joint inflammation in one or a few joints. Intraarticular glucocorticoids are often used with success in these patients; however, injections often have to be repeated periodically and there are concerns for the long-term consequences of injected glucocorticoids. Intraarticular injection of [...]
