A Class of Commonly Prescribed Anti-Depressants May Reduce inflammation in Inflammatory Arthritis


Limited data have suggested that the selective-serotonin reuptake inhibitors (SSRIs) may have anti-inflammatory properties in addition to their antidepressant effects.  Here, Sacre et al (Arthritis Rheum 2010; 62(43): 683) explore the mechanisms of two SSRIs (fluoxetine and citalopram) in models of experimental arthritis. Methods Inflammation was induced in the paws of male DBA/1 mice by […]

Intraarticular Injection of Infliximab not Effective in Patients with Inflammatory Arthritis


Despite systemic administered therapies, some patients with inflammatory arthritis continue to have chronic or recurrent joint inflammation in one or a few joints.  Intraarticular glucocorticoids are often used with success in these patients; however, injections often have to be repeated periodically and there are concerns for the long-term consequences of injected glucocorticoids.  Intraarticular injection of […]