Is TNF Inhibitor Therapy Effective at Preventing Bony Ankylosis in Ankylosing Spondylitis?

TNF-α blockade in patients with ankylosing spondylitis (AS) has been shown to improve clinical symptoms of disease and physical function.  However, a benefit in reducing the incidence or severity of axial ankylosis has not been demonstrated.  In fact, qualified observational data has suggested that radiographic progression of ankylosis and inflammation may be unrelated in AS.  […]