Golimumab (Simponi®)

What is Golimumab (Simponi®)?

Golimumab is in a class of drugs called biologics.  Golimumab is a treatment for adults with moderate to severe rheumatoid arthritis, active psoriatic arthritis, or active ankylosing spondylitis. It is injected under the skin to reduce signs and symptoms of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, such as joint swelling, pain, fatigue, and length of morning stiffness.  Golimumab is commonly known as Simponiâ.

How do I take it?    

Golimumab comes in a prefilled syringe (needle) or an automatic injector (pen). You should be instructed on how to give yourself injections by a healthcare professional.  Each syringe or pen holds 50 mg of medication. You will self inject one dose every 4 weeks. This medication must be refrigerated.  Do not freeze this medicine.

What about side effects?

The most common side effect is serious infection. Golimumab can lower the body’s ability to fight infection.  Be sure to contact your physician if you have any type of infection or if you are planning a surgery. You may have to stop Golimumab while being treated for an infection.

You will need to have a negative tuberculosis (TB) skin test before beginning Golimumab therapy.   You should also have negative tests for hepatitis B.

You should not take a live vaccine (Flu-Mist, chicken pox vaccine, shingles vaccine) while on Golimumab.  The flu-shot is not a live virus and all patients should consider having this vaccination yearly. Occasionally some patients develop a reaction at the injection site, such as redness, pain or swelling.  Notify your doctor to find out the best way to handle any reactions.

What about other medications?

When you are taking Golimumab, it is very important that your doctors know if you are taking any other medicine. This includes prescription and non-prescription medicines as well as birth control pills, vitamins, and herbal supplements.  Golimumab can be taken with other medications – NSAIDS (Celebrexâ, ibuprofen, naproxen), prednisone, methotrexate, and hydroxychloroquine.

What else should I know?

You must continue your regular visits to the rheumatologist. Your doctor will monitor you for any improvements in your disease and for any signs of infections. Most patients notice an improvement in symptoms after the first or second injection.

Updated: April 25, 2012

Victoria Ruffing, RN

About Victoria Ruffing, RN

Ms. Ruffing has been a member of the Arthritis Center since 2000, currently serving as the Nurse Manager. She is a critical member of our patient care team.