Optimal Colchicine Dosage for Acute Gout Explored


Despite being used for decades as a primary treatment for acute gout, optimal colchicine dosing has not been systematically evaluated. This is potentially important, as higher doses of colchicine can frequently be associated with the undesired consequence of severe diarrhea and gastrointestinal distress.

Does Tuberculosis Risk Differ Among TNF Inhibitors?


Reactivation of latent tuberculosis is a recognized risk of TNF inhibitor use.  While there has been circumstantial evidence of greater risk with the monoclonal antibody TNF inhibitors (e.g. infliximab and adalimumab) compared with decoy receptor TNF inhibitors (e.g. etanercept), there have been few direct comparisons.  Here, Dixon et al (Ann Rheum Dis 2010; 69: 522-528) […]

A Class of Commonly Prescribed Anti-Depressants May Reduce inflammation in Inflammatory Arthritis


Limited data have suggested that the selective-serotonin reuptake inhibitors (SSRIs) may have anti-inflammatory properties in addition to their antidepressant effects.  Here, Sacre et al (Arthritis Rheum 2010; 62(43): 683) explore the mechanisms of two SSRIs (fluoxetine and citalopram) in models of experimental arthritis. Methods Inflammation was induced in the paws of male DBA/1 mice by […]

Immunization Responses with Rituximab Explored


Treatment with rituximab, a monoclonal antibody targeting CD20+ B cells, could adversely affect immunization responses by dampening the antibody response from new vaccination or reducing pre-formed antibody from prior vaccination.  However, little systematic investigation of immunization responses has been undertaken.  Here, two studies concurrently published in Arthritis & Rheumatism explore responses after influenza vaccination (van […]

Can Measuring Polyglutamated Methotrexate in Red Blood Cells Help Guide Dosing


Measuring the amount of polyglutamated methotrexate within red blood cells has been proposed as an objective method of tracking medication response and predicting drug toxicity.  However, there are only limited data evaluating this method.  Here, Stamp et al (Arthritis Rheum 2010; 62(2)): 359) cross-sectionally explore the associations of RBC polyglutamated methotrexate levels with disease activity […]