Are the Incidence and Prevalence of RA Changing in the United States?


The epidemiology of rheumatoid arthritis (RA) is influenced by a number of factors, including survival, changes in diagnostic tools, and temporal trends in environmental factors that may promote or protect from disease.  Here, Myasoedova et al (Arthritis Rheum 2010; 62(6): 1576) explore the trends in RA incidence and prevalence over 50 years in a population-based […]

Dynamic Knee Alignment During Walking as a Risk Factor for Knee Osteoarthritis


Knee alignment may be different during walking than when at rest.  Prior studies have identified varus thrust, a worsening of bow-leg alignment that occurs only during the weight bearing phase of walking, as a risk factor for developing knee osteoarthritis (OA).  Valgus thrust, or knock-knee alignment during walking, may also increase the risk of knee […]

Leflunomide and Pregnancy Outcomes Explored


Leflunomide use during early pregnancy is associated with fetal malformations in animal studies and is classified as a pregnancy category X by the U.S. Food and Drug Administration.  However, little is known about pregnancy outcomes in humans exposed to leflunomide in early pregnancy, particularly in those who receive “wash-out” with cholestyramine (a drug sequestrant).   Here, […]

Targeting Interleukin-17 Studied in Rheumatoid Arthritis


Recently, it has been recognized that a subset of T cells producing the cytokine IL-17 contribute to the pathogenesis of rheumatoid arthritis (RA).  Animal studies have suggested that blockade of IL-17 may reduce the inflammatory signs and symptoms of inflammatory arthritis and reduce bone erosion.  Here, Genovese et al report Phase I/II data for LY2439821, […]