Prednisone’s affect on SED rate Question I just had blood work done at the request of my hand surgeon. I have been taking 5 mg prednisone every other day for pain in my wrist for a couple weeks (different doctor prescribed it). Will that affect the SED rate results? Answer March 30, 2007 By Alan Matsumoto, M.D. Although prednisone can decrease the sed rate, the dose you are taking is so low, I think it is unlikely that it will have much effect.