Over time prednisone can have the following effects:
weight gain, thinning of the skin with easy bruising, loss of bone (osteoporosis and fractures), necrosis or death of bone at the knee or hip, diabetes, high blood pressure, heart disease, and increased risk of infection.
Sounds nasty, doesn’t it? There are other drugs for lupus that allow folks to come off the steroids – for example, cell cept, methotrexate. You should discuss these with your rheumatologist.